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Solutions / Clinical Trials

Clinical trial compensation — HIPAA-compliant, flexible, and built for retention

HIPAA-compliant · SOC 2 Type II · PCI DSS

TruCentive automates delivery of clinical trial participant compensation and reimbursement via email, SMS, or in-person bulk links — with full HIPAA de-identification, a complete audit trail, and 100% of unclaimed rewards returned to your account.

85%
of clinical trials fail to enroll enough patients, leading to significant delays (Parexel)
23%
better participant retention when subjects choose their own compensation
100%
of unclaimed compensation returned to your account automatically

Traditional clinical trial compensation strategies cost programs time, money, and — most critically — participants. Approximately 25–30% of Phase III trial participants drop out before a study completes. TruCentive gives research coordinators the tools to design compelling compensation programs, automate delivery and reminders, and return every unclaimed dollar to the study budget automatically.

Use cases

Every clinical trial compensation program, automated

TruCentive supports the full range of clinical trial compensation from a single platform — study visits, travel, milestones, and multi-wave studies. Build once, automate the delivery, and get unused budget back automatically.

Study visit compensation

Deliver participant compensation immediately after each study visit — in the clinic or remotely. Supports individual ad-hoc sends and bulk file upload for high-volume trials. Automated reminders increase claim rates without coordinator intervention.

Per-visit deliveryAd-hoc and bulk sendAutomated remindersEdit, resend, revoke

Travel reimbursement

Reimburse participants for travel, parking, and lodging expenses without handling cash or checks. Prepaid Visa and PayPal options give participants flexibility. Full financial audit trail for sponsor reporting.

Prepaid Visa / MastercardPayPal and VenmoMailed check optionSponsor audit trail

Milestone completion rewards

Reward participants for reaching key study milestones — screening completion, first dose, mid-study assessment, and final visit. Automate delivery so coordinators focus on the trial, not the logistics.

Screening completionFirst dose deliveryMid-study rewardsFinal visit bonus

Longitudinal and multi-wave studies

Manage compensation across multiple study waves from a single project. Schedule payments at Day 0, Day 30, Day 90, or trigger on milestone completion. Reminders stop automatically when the participant claims.

Multi-wave automationFlexible schedulingAuto-stop on claimWave-by-wave reporting

In-person and on-site delivery

Export bulk compensation links for in-person distribution at clinical sites. Participants receive a printed or on-screen QR code and claim their compensation on their own device at their own pace — no email required.

Bulk link exportQR code deliveryNo email requiredOn-site claim pages

Decentralized and remote trials

Support decentralized clinical trial (DCT) models with fully remote compensation delivery. Participants receive and claim rewards from home via email or SMS — maintaining engagement without site visits.

DCT and virtual trialsEmail and SMS delivery120+ countriesLocal currency support

Three principles

What makes a clinical trial compensation program work

The best clinical trial compensation programs share three foundations. TruCentive is designed to support all three.

01

Easy

Straightforward compensation allows coordinators to allocate their time to the trial rather than logistical issues. For subjects, prompt and hassle-free compensation is a tangible acknowledgment of their valuable participation — and builds the trust that keeps them in the study.

  • → Add subjects individually or by bulk file upload
  • → Edit, resend, or revoke any delivery
  • → Automated reminders reduce coordinator workload
  • → Ad-hoc and scheduled delivery in one platform
02

Compelling

Approximately 30% of studies are terminated early because they cannot enroll enough participants. Compelling compensation options attract more diverse subjects and retain them longer. 86% of subjects select a variety of gift cards throughout the course of any given study — choice drives engagement.

  • → 100,000+ reward options participants actually want
  • → Top choices: Visa, Amazon, Target, Starbucks, Best Buy
  • → Choice improves enrollment and retention by 23%
  • → Localized options for international trials
03

Flexible

Flexibility in managing compensation delivery via SMS, email, or in-person — with the ability to resend, edit, or revoke deliveries — simplifies ongoing management across complex, multi-site, multi-wave studies. Subject flexibility in choice respects participant autonomy and meets diverse needs.

  • → Email, SMS, or in-person bulk link delivery
  • → Multi-site and decentralized trial support
  • → Multi-wave longitudinal compensation automation
  • → 120+ countries, local currencies, PayPal in 300+

Platform features

Built for research coordinators managing complex studies

Design, deliver, and track clinical trial compensation without administrative overhead. TruCentive connects to your study management tools via API and handles everything from delivery to refund automatically.

HIPAA de-identification

When de-identification is active, all email addresses of subjects enrolled in a compensation program are permanently anonymized within TruCentive. Subject IDs can be used to maintain tracking without storing personally identifiable information — allowing your team full platform access without data privacy concerns.

  • · Permanent anonymization of all subject PII
  • · Subject ID tracking preserves compensation records
  • · Project-based, personalized, and branded
  • · Suitable for IRB review and institutional compliance

Campaign builder

Design the full subject journey — initial compensation delivery, automated reminder schedule, and post-claim follow-up — without any code. Start from a pre-built clinical trial template or build from scratch. Your institution’s logo is applied automatically.

  • · Pre-built clinical trial compensation templates
  • · Email, SMS, and in-person bulk link delivery
  • · Personalized messaging with subject ID and study name
  • · Mobile-optimized claim pages for any device

Automation and reminders

Set a reminder schedule once and TruCentive handles everything. Reminders automatically stop when the subject claims — so coordinators never send a reminder to someone who has already received their compensation. Multi-wave study automation handles Day 0, Day 30, and Day 90 payments from a single project setup.

  • · Typical cadence: Day 0, Day 1, Day 5, Day 15, final 5 days before expiry
  • · Auto-stop on claim — no over-reminding
  • · Multi-wave longitudinal compensation from one project
  • · Expiry rules return unclaimed value to your budget automatically

Reporting and audit trail

Every delivery, claim, and refund is tracked with a complete audit trail — suitable for sponsor reporting, IRB submission, and institutional finance sign-off. Real-time visibility into claim rates by subject, study arm, and site.

  • · Per-subject delivery and claim status
  • · Claim rate tracking by study arm and site
  • · Full refund and unclaimed compensation reporting
  • · Enterprise: multi-account, multi-site reporting

Compensation options

100,000+ compensation options participants actually want

When subjects choose their own compensation — rather than receiving a fixed gift — retention improves by 23% and perceived value increases. TruCentive offers the industry’s most extensive catalog, from everyday essentials to flexible payments.

Visa, Mastercard, AmexPrepaid cards — most flexible
PayPal and Venmo300+ countries supported
AmazonTop choice in most trials
Target, WalmartEssentials and groceries
Starbucks, restaurantsEveryday rewards
CVS, WalgreensHealthcare and wellness
Local merchantsBy ZIP code — 100,000+
ACH bank depositDirect to bank account
Mailed checkPhysical check option

Common questions

Frequently asked questions

Yes. TruCentive’s Enterprise plan includes HIPAA-compliant recipient de-identification. All email addresses of subjects enrolled in a compensation program are permanently anonymized within TruCentive. Subject IDs can be used to maintain compensation tracking records without storing personally identifiable information. TruCentive is also SOC 2 Type II certified and PCI DSS compliant.
When de-identification is active, all email addresses of subjects enrolled in a compensation program are permanently anonymized within TruCentive. Subject IDs can be included to maintain tracking and compensation records without compromising personally identifiable information. This allows your team full platform access for funds management, reporting, and project design without data privacy concerns. De-identification is project-based and can be applied selectively.
TruCentive supports over 100,000 reward options including gift cards from 50,000+ brands, prepaid Visa, Mastercard, and Amex cards, PayPal, Venmo, ACH bank deposit, and mailed check. The top five choices among clinical trial participants are Visa, Amazon, Target, Starbucks, and Best Buy. Offering participant choice improves retention by 23%.
TruCentive returns 100% of unclaimed compensation to your account at the expiry date you set. There is no manual request process. Unclaimed clinical trial compensation is a significant budget drain under breakage-based platforms — TruCentive eliminates this. In 2025, TruCentive returned over four million dollars in unclaimed value to customers.
Yes. TruCentive supports delivery to participants in over 120 countries with gift cards in local currencies. PayPal covers 300+ countries for flexible payment-based compensation. Bulk link export supports in-person delivery at clinical sites without requiring participants to have an email address — ideal for on-site visit compensation.
Yes. TruCentive’s bulk link export generates unique compensation links that can be printed or displayed as QR codes at clinical sites. Participants scan or enter the link on their own device and choose their compensation at their own pace — no email address required for delivery.
Yes. You can sign up for free with no credit card required and build and preview projects using zero-value sample messages. TruCentive also offers a free 30-minute design session where the team builds a complete clinical trial compensation project with your institution’s branding, study structure, and reward selections.

Other TruCentive solutions

TruCentive supports HR, sales, marketing, research, and agency programs on the same platform.

Get started

See a clinical trial compensation project built live in 30 minutes

Book a free design session and leave with a complete, ready-to-send project — your institution’s branding, your study structure, your compensation selections. No credit card required.

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