Managing Research Trial Payouts

From Enterprise to Individual Studies

In research studies, participant payments and compensation are critical to study retention, ethics compliance, and efficiency.

Running these payments effectively requires great tools and a clear organizational structure that ensures accountability, compliance, and simple, seamless execution.

A three-tiered administrative hierarchy is an effective model for managing research payout systems. It balances control, oversight, and operational ease at all levels from enterprise-level strategy to day-to-day study execution.

By combining flexibility, compliance, and participant-focused features, TruCentive offers a leading solution for research study payout administration.

research trial personnel

Compensation should recognize the value of a participant’s time, effort, and contribution, not merely offset inconvenience.

— Ezekiel J. Emanuel, MD, PhD, bioethicist and former chair of the Department of Bioethics at the NIH

Clinical trial structure for managing research trial payouts

Why a Hierarchical Approach Matters

Many research teams still use fragmented and manual workflows when dealing with payouts.

  • Coordinators manually process stipends
  • Finance teams struggle to reconcile accounts
  • Investigators juggle Institutional Research Board (IRB) approvals alongside participant payouts.

This approach can potentially lead to delayed and/or missed payments, compliance gaps (HIPAA, SOC2 Type 2, IRS reporting) and a wasteful and Inefficient use of staff time

A three-tiered hierarchy brings clarity to roles and responsibilities, ensures proper approvals at each level, and leverages automation for speed and accuracy. TruCentive makes it simple to run clinical payments that are compliant and secure.

  • Enterprise Administrators allocates departmental funds and approves high-level rules.
  • Department Administrators creates a study, funds it, and grants access to coordinators.
  • Investigators and coordinators execute payouts, monitor progress, send notifications, and maintain compliance.

This hierarchy ensures that decisions are made at the right level. Compliance is maintained and helps ensure that errors are minimized across multiple studies.

man discussing research trial tasks with researcher

The Roles:

1. Enterprise Administrators

Strategic Oversight and Global Control

At the top of the hierarchy are the Enterprise Administrators that have top-level responsibility for a research organization’s entire research payout environment.

Key Responsibilities:

User and Access Management

  • Create, manage, and audit administrative users across all studies and departments.
  • Establish role-based access rules to protect sensitive data while maintaining efficiency.

Fund Management

  • Responsible for moving funds between accounts and ensuring adequate liquidity for all studies.
  • Oversee treasury and finance aspects of the payout system, ensuring budget alignment at the organizational / enterprise level.

Operational Oversight

  • Monitor system-wide performance and compliance.
  • Maintain access to all system data except protected HIPAA information.
  • Ensure alignment with the organization’s goals for clinical operations and financial accountability.

Enterprise Administrators serve as the overall architects and gatekeepers for both compliance and control. They have centralized oversight of the payout system.

They guide the individual department administrators in best practices and in aligning with the organization’s principles.

Enterprise Administrators have the overall responsibility and authority to monitor the system and prevent errors that could cascade across multiple studies and departments.

2. Department Administrators

Budget Control and Study-Level Leadership

Department Administrators act as the bridge between enterprise-level strategy and the Principal Investigators and Coordinators responsible for individual study execution. They create the basis for individual studies and manage the personnel, budgets, funding and creative direction of individual studies.

Key Responsibilities:

Budgetary Oversight

  • Control department-level funds and approve budgets for each study.
  • Track departmental spending to ensure that studies remain within allocated resources.

Study Management

  • Create, staff, and fund new studies within the payout system.
  • Manage administrative users at the department level, ensuring coordinators have access.

Operational Efficiency

  • Simplify study creation and funding, making it easy for coordinators to execute payouts.
  • Provide department-level visibility into study financials without exposing sensitive HIPAA data.

Department Administrators are the central layer of financial accountability and management oversight. They ensure studies are appropriately funded, staffed with competent personnel, and that the logistics are operationally ready.

Department Administrators guide the Principal Investigators and Coordinators in administrative matters relating to payout and remove friction for coordinators and investigators by streamlining administrative processes and enforcing financial discipline.

3. Study Investigators and Coordinators

Execution and Participant Focus

Principal Investigators and Coordinators, who manage the daily execution of the payout system, have access and responsibility for individual studies. They handle the authority for approving research participant payouts, compliance, communication, administering payments, sending notifications, HIPAA de-identification as well as IRS reporting.

Key Responsibilities:

Day-to-Day Payout Administration

  • Administer all research participants’ payments using pre-designed templates.
  • Ensure studies are adequately funded for all payouts.
  • Monitor progress, track milestones, and confirm each participant receives timely compensation.

Compliance and Security

  • Conduct HIPAA de-identification to protect participant privacy.
  • Help ensure SOC2 Type 2 compliance, maintain data security and operational controls.
  • Maintain audit-ready records for each transaction, including IRS 1099 reporting and payout notifications.

Communication and Security

  • Manage email and SMS notifications that the payout system automatically generates.
  • Edit and resend notices as needed, keeping participants informed and engaged.

System Optimization and Waste Reduction

  • Recapture forgotten payments, eliminating waste and ensuring full compliance.
  • Track the status of all study payouts in real-time, identifying issues or missed transactions.
  • Leverage system automation to deliver payments quickly.

How the Three Tiers Work Together

A hierarchical system is effective because it combines oversight, control, and execution

research trial administrative responsibility

Tier

Role

Key Focus

Examples

Enterprise Administrators

Global oversight

Policy, fund management, system-wide compliance

Approve budgets, manage users, move funds, monitor all studies

Department Administrators

Study-level management

Budget control, department operations

Fund studies, create studies, manage department admins, monitor department financials

Study Investigators & Coordinators

Daily execution

Participant payouts, compliance, communication

Administer payments, send notifications, HIPAA de-identification, IRS reporting

Benefits

Operational Efficiency

Coordinators can focus on participant experience rather than administrative logistics. Departments can create and fund studies quickly without waiting for enterprise approval for each step.

Compliance Assurance

A tiered oversight models safeguards that both HIPAA and SOC2 Type 2 requirements are consistently applied. For payments, IRS reporting and audit trails are automatically tracked and managed at every level.

Financial Control and Transparency

Enterprise and Department Admins can view financial rollups to monitor budget utilization. Waste is minimized by recapturing missed payments and by catching correcting errors quickly.

Scalability

Adding new studies or departments doesn’t disrupt or modify existing workflows. Study size isn’t an issue to accommodate large, multi-site studies without increasing operational complexity.

Participant Satisfaction

Automated, timely payouts as well as consistent branding and communications style enhance trust, participant confidence and retention. Coordinators can maintain personalized communication while leveraging automation efficiency.

Implementation

When research institutions are planning to implement this model a number of best practices should be part of the planning process:

Define Roles and Responsibilities Clearly

  • Establish enterprise-level, department-level, and study-level responsibilities.
  • Align access levels to the principle of least privilege to protect sensitive data.

Leverage Automation

  • Use pre-built templates for payouts and notifications to minimize manual entry.
  • Automate audit logging and compliance reporting to reduce administrative burden.

Integrate with Existing Systems

  • Connect the payout system with Clinical Trial Management System (CTMS,) finance.
  • Leverage management tools for real-time budget tracking.

Training

  • Enterprise Administrators need to understand system-wide rules and compliance oversight.
  • Department Administrators should be comfortable managing budgets and the mechanics of funding studies.
  • Coordinators must master operational tasks, participant communication, and reporting.
TruCentive logo carrot top

Monitor and Continuously Optimize

  • Use dashboards to track payout completion rates, funding status, and participant engagement.
  • Adjust roles, templates, or automation rules to continually improve efficiency and compliance.

Efficiency, Compliance, and Trust

Managing participant payments in research studies doesn’t have to be chaotic.

Incentive Automation that allows for a three-tiered administrative hierarchy provides simple manageability, operational clarity, accountability, and operational efficiency.

Roles ensure that responsibility are correctly distributed among study management. Enterprise Administrators oversee system-wide policies and finances. Department Administrators manage study creation, funding, and management of department-level users, and Investigators and coordinators handle the day-to-day execution, participant communication, and compliance.

Together, these tiers create a scalable, compliant, and participant-focused payout system. Principle Investigators and coordinators have more time for science, sponsors gain financial transparency, and participants experience faster, reliable payments, while maintaining strict compliance with HIPAA, SOC2 Type 2, and IRS regulations.

Participant experience, compliance, and operational efficiency are paramount. TruCentive’s three-tiered payout management model is the best practice for research administration.

Why TruCentive Stands Out

TruCentive is designed to remove the headaches of research payout management. This means research and administrative teams can focus on the important tasks rather than worrying about how to deliver payouts. Automation ensures that every participant feels valued, while the reporting features give leaders clarity about performance.

The ability to scale is what sets it apart. Whether a company needs to send fifty transactions a month or fifty thousand, the process remains consistent. No manual work, no delays, and no wasted resources.

researcher

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